Protein electrophoretic patterns of serum and peritoneal fluid in normal, tumor-bearing, and immune mice.

Statistically significant alterations were observed in protein fractions of sera and peritoneal fluids of Ehrlich ascitos tumorbearing mice and mice immunized to this tumor when they were compared to normal mice. Of special interest is the in creased y-globulin fraction found in immune mouse sera and peritoneal fluid. The increased y-globulin in peritoneal fluid occurs without any significant alteration of total protein of the peritoneal fluid. The interactions of the protein changes in the three groups of mice studied are not fully realized. However, their probable direct participation in the humoral destruction of tumor cells at their growth site in the immune mice is cor related. The results of this study demonstrate a portion of the host's physiologic role in the potential retardation of tumor